Get Apoptosis, Cell Signaling, and Human Diseases: Molecular PDF

By Rakesh Srivastava

ISBN-10: 1588296776

ISBN-13: 9781588296771

ISBN-10: 1588298825

ISBN-13: 9781588298829

ISBN-10: 1597451991

ISBN-13: 9781597451994

(for either volumes) Apoptosis, telephone Signaling, and Human ailments: Molecular Mechanisms, Volumes 1 & 2, current a concise synthesis of contemporary advancements within the knowing of either mobile survival and apoptotic pathways. specific recognition is given to apoptosis in human ailments, akin to diversified sorts of melanoma and neurodegenerative illnesses. those entire volumes combine the main leading edge and present findings from numerous similar disciplines of clinical examine, together with pathology, genetics, virology, mobile biology, immunology, and molecular biology. quantity 1 is split into sections: "Malignant Transformation and Metastasis" and "Molecular foundation of disorder Therapy." quantity 2 follows an identical constitution and is split into sections entitled "Kinases and Phosphate" and "Molecular foundation of telephone Death." the entire participants are on the leading edge of clinical discovery, and the experiences they current systemically study the main interesting and cutting edge facets in their specific components of workmanship. Researchers will locate those volumes of significant profit as they look for novel and more beneficial remedies for human illnesses.

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Extra resources for Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms

Sample text

Nuclear translocation of the catalytic subunit of protein kinase A induced by an antisense oligonucleotide directed against the RIalpha regulatory subunit. Oncogene 2001;20:8019–8024. 44. Nesterova MV, Ulmasov KHA, Abdukarimov A, Aripdzhanov AA, Severin ES. Nuclear translocation of cAMP-dependent protein kinase. Expl Cell Res 1981;132:367–373. 45. Aprikian AG, Nesterova MV, Glukhov AI, Severin ES. Binding of a holoenzyme and cAMPdependent protein kinase subunits with cell nuclei. Biochemistry (NY)1987;52: 1118–1124.

19. Showers MO, Maurer RA. A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem 1986;261:16,288–16,291. 20. Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T. Molecular cloning of a unique tissue-specific protein kinase (C-gamma) from human testis—representing a third isoform for the catalytic subunit of the cAMP-dependent protein kinase. Mol Endocrinol 1990;4:465–475. 21. Ulmasov KhA, Nesterova MV, Severin ES. cAMP-dependent protein kinase from pig brain: subunit structure, mechanism of autophosphorylation and dissociation into subunits under the action of cAMP.

155. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001;2:599–609. 156. Conkright MD, Guzman E, Flechner L, et al. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell 2003;11:1101–1108. 157. Montminy MR, Bilezikjian LM. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 1987;328:175–178. 158. Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman HM.

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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms by Rakesh Srivastava


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